General Product Application Suitability | Depth Filtration | ||||
Inorganic solids | Organic solids | Aggressive chemicals or processes | High-dirt holding capacity | High retention | |
PROCLEAR PP | |||||
PROCLEAR GF | |||||
PROCLEAR GP |
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Polypropylene depth media
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Micron rating from 0.6 to 100µm
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Extremely robust, capable of withstanding aggressive conditions
•Aggressive chemicals, high / low pH•Physical factors (temperature, flow rate, differential pressure etc.) -
Example application: particulate removal prior to sterilising filter buffers
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Glass fibre depth media
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Micron rating from 0.6 to 10µm
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Highly retentive
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High dirt-holding capacity
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Example application: Clarification of bioreactor output prior to downstream processing
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Glass fibre / polypropylene composite depth media
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Micron rating from 0.5 to 0.6µm
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Extremely retentive
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High dirt-holding capacity
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Assurance against particle shedding
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Example application: Growth media pre-filtration
General Product Application Suitability | Membrane Filtration | ||||||||||
Sterilising grade | Mycoplasma retentive | Bioburden reduction | Growth media | Buffers | Product stream | Difficult to filter solutions | Solvents of agressive chemicals | Aqueous solutions | Water filtration | Sterile air/gas | |
PROPOR SG | |||||||||||
PROPOR HC | |||||||||||
PROPOR BR |
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Polyethersulfone (PES) membrane
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0.2µm rated, sterilising grade
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Also available in 0.1µm and 0.45µm
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High flow rates = smaller filter required / quicker processing time
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High throughputs = larger batches
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Low product binding = higher product yield
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Broad-spectrum chemical compatibility
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Low extractables = low leachables into drug product
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Example applications: buffer filtration, final fill
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Polyethersulfone (PES) membrane
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0.2µm rated, sterilising grade
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Integral PES highly asymmetric pre-filter layer
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High capacity, high dirt holding = high throughput with difficult to filter products
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Broad-spectrum chemical compatibility
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Example application: Growth media filtration
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Polyethersulfone (PES) membrane
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0.2µm nominally rated, non-sterilising
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Integral polyester pre-filter layer
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Bioburden reduction
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>5log reduction ASTM F838
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High flow rates = smaller filter required / quicker processing time
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Low product binding = higher product yield
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Broad-spectrum chemical compatibility
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Example application: Chromatography or TFF pre-filtration